Pharmaceutics & Dosage Forms

Dosage Form

TRFarmasötik Dozaj Şekli
Also known as:Pharmaceutical form · Dosage formulation

The physical form in which a drug is manufactured and administered, combining the active substance with excipients, for example a tablet, capsule, solution, suspension, injection, cream, transdermal patch or inhalation powder.

In depth

Dosage forms are classified by physical state (solid, semi-solid, liquid, gaseous) and by intended route (oral, parenteral, topical, inhaled, rectal and others). The choice of dosage form influences the rate and extent of absorption, onset and duration of action, stability, dosing accuracy and patient acceptability.

Standard terms are harmonised in the European Pharmacopoeia and the EDQM Standard Terms, and the pharmaceutical form is stated in section 3 of the Summary of Product Characteristics (in Turkey, the KÜB approved by TİTCK). Products containing the same active substance in different dosage forms are not automatically interchangeable.

Clinical pearl

Crushing or splitting tablets can destroy modified-release or enteric-coated properties, causing dose dumping or loss of protection; check whether an alternative such as an oral liquid is available before altering a dosage form.

TRIn Turkish

Farmasötik Dozaj Şekli

Etkin maddenin yardımcı maddelerle birleştirilerek üretildiği ve uygulandığı fiziksel formdur; tablet, kapsül, çözelti, süspansiyon, enjeksiyonluk çözelti, krem, transdermal flaster ve inhalasyon tozu buna örnektir.

Farmasötik dozaj şekilleri fiziksel hâllerine (katı, yarı katı, sıvı, gaz) ve amaçlanan uygulama yoluna (oral, parenteral, topikal, inhalasyon, rektal vb.) göre sınıflandırılır. Dozaj şeklinin seçimi absorpsiyonun hızını ve derecesini, etkinin başlangıcını ve süresini, stabiliteyi, doz doğruluğunu ve hastanın kabulünü etkiler.

Standart terimler Avrupa Farmakopesi ve EDQM Standart Terimleri ile uyumlaştırılmıştır; farmasötik form Kısa Ürün Bilgisi'nin 3. bölümünde (Türkiye'de TİTCK tarafından onaylanan KÜB'de) belirtilir. Aynı etkin maddeyi farklı dozaj şekillerinde içeren ürünler birbirinin yerine kendiliğinden kullanılamaz.

Tabletlerin ezilmesi veya bölünmesi değiştirilmiş salımlı ya da enterik kaplı formların özelliğini bozarak doz boşalmasına (dose dumping) veya koruyucu etkinin kaybına yol açabilir; dozaj şekli değiştirilmeden önce oral sıvı gibi bir alternatif aranmalıdır.

Diğer adları:Farmasötik form · Dozaj şekli · Dozaj formu
Updated 24.09.2026 0 views Educational reference — verify against current sources before clinical use.

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Route of AdministrationUygulama Yolu

The path by which a drug is brought into contact with the body, such as oral, sublingual, rectal, intravenous, intramuscular, subcutaneous, inhaled, topical or transdermal.

 ExcipientYardımcı Madde

Any constituent of a medicinal product other than the active substance, added to enable manufacture, maintain stability, control release, improve acceptability or aid administration.

 Active Pharmaceutical IngredientEtkin Madde

The substance in a medicinal product that is responsible for its pharmacological activity, as distinct from the excipients; in manufacturing terms it is the drug substance produced under GMP.

 Modified-Release FormulationDeğiştirilmiş Salımlı Formülasyon

A dosage form in which the rate, timing or site of drug release is deliberately altered from that of a conventional product, as in prolonged-release, delayed-release and pulsatile preparations.

 Enteric CoatingEnterik Kaplama

A polymer coating on tablets, capsules or pellets that resists dissolution in acidic gastric fluid and dissolves at the higher pH of the small intestine, delaying drug release until the dosage form has left the stomach.

 BioavailabilityBiyoyararlanım

The fraction of an administered dose that reaches the systemic circulation unchanged, and the rate at which it does so; by definition, bioavailability is 1 (100%) for an intravenous dose.