Pharmaceutics & Dosage Forms

Enteric Coating

TREnterik Kaplama
Also known as:Gastro-resistant coating

A polymer coating on tablets, capsules or pellets that resists dissolution in acidic gastric fluid and dissolves at the higher pH of the small intestine, delaying drug release until the dosage form has left the stomach.

In depth

Enteric polymers such as methacrylic acid copolymers, cellulose acetate phthalate and hydroxypropyl methylcellulose phthalate carry acidic groups that ionise and dissolve above about pH 5–7. Enteric coating protects acid-labile drugs from degradation (proton pump inhibitors, erythromycin), protects the stomach from irritant drugs (aspirin, diclofenac) or targets release to the intestine (mesalazine).

Because gastric emptying of a single-unit tablet is variable, enteric-coated products show a lag time and a variable Tmax, particularly when taken with food; in product information such forms are designated gastro-resistant.

Clinical pearl

Enteric coating reduces local gastric irritation but not the systemic risk of peptic ulcer and bleeding from aspirin or NSAIDs; enteric-coated tablets must not be crushed or chewed, and antacids taken at the same time may cause premature release.

Example drugs

Omeprazole Erythromycin aspirin Diclofenac Mesalazine
TRIn Turkish

Enterik Kaplama

Tablet, kapsül veya peletlere uygulanan, asidik mide sıvısında çözünmeye direnç gösteren ve ince bağırsağın daha yüksek pH'ında çözünerek ilaç salımını dozaj şekli mideden çıkana kadar geciktiren polimer kaplamadır.

Metakrilik asit kopolimerleri, selüloz asetat ftalat ve hidroksipropil metilselüloz ftalat gibi enterik polimerler, yaklaşık pH 5–7'nin üzerinde iyonlaşıp çözünen asidik gruplar taşır. Enterik kaplama asitte kararsız ilaçları yıkımdan korur (proton pompası inhibitörleri, eritromisin), mideyi tahriş edici ilaçlardan korur (aspirin, diklofenak) veya salımı bağırsağa hedefler (mesalazin).

Tek birimli bir tabletin mideden boşalması değişken olduğundan enterik kaplı ürünler, özellikle yemekle alındığında, gecikme süresi ve değişken Tmax gösterir; ürün bilgilerinde bu formlar gastro-rezistan olarak adlandırılır.

Enterik kaplama midede lokal tahrişi azaltır, ancak aspirin veya NSAİİ'lere bağlı sistemik peptik ülser ve kanama riskini ortadan kaldırmaz; enterik kaplı tabletler ezilmemeli veya çiğnenmemelidir, aynı anda alınan antasitler erken salıma neden olabilir.

Diğer adları:Gastro-rezistan kaplama
Updated 24.09.2026 1 views Educational reference — verify against current sources before clinical use.

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Modified-Release FormulationDeğiştirilmiş Salımlı Formülasyon

A dosage form in which the rate, timing or site of drug release is deliberately altered from that of a conventional product, as in prolonged-release, delayed-release and pulsatile preparations.

 Lag TimeGecikme Süresi

The delay between drug administration and the first appearance of measurable drug in the systemic circulation, before absorption begins.

 DissolutionÇözünme (Dissolüsyon)

The process by which a solid drug passes into solution in a solvent such as gastrointestinal fluid; for solid oral dosage forms it is a prerequisite for absorption and often its rate-limiting step.

 Dosage FormFarmasötik Dozaj Şekli

The physical form in which a drug is manufactured and administered, combining the active substance with excipients, for example a tablet, capsule, solution, suspension, injection, cream, transdermal patch or inhalation powder.

 Time to Maximum ConcentrationMaksimum Konsantrasyona Ulaşma Süresi

The time after dosing at which the maximum plasma concentration (Cmax) is observed; an index of the rate of drug absorption.