Pharmaceutics & Dosage Forms

Depot Injection

TRDepo Enjeksiyon
Also known as:Long-acting injectable · Depot preparation

A parenteral preparation, usually given intramuscularly or subcutaneously, that forms a reservoir at the injection site from which the drug is released slowly over weeks to months.

In depth

Prolonged release is achieved with oily solutions of lipophilic esters (haloperidol decanoate, fluphenazine decanoate), aqueous micro- or nanocrystalline suspensions (paliperidone palmitate, aripiprazole, medroxyprogesterone acetate), biodegradable polymer microspheres or implants (leuprorelin, goserelin) and poorly soluble salts (benzathine benzylpenicillin). Absorption from the depot is rate-limiting, so the apparent half-life reflects release rather than elimination (flip-flop kinetics).

With some products steady state is reached only after several months, so oral supplementation or a loading regimen may be needed at the start of treatment.

Clinical pearl

Long-acting injectable antipsychotics improve adherence, but adverse effects can persist for weeks after the last injection; tolerability should first be established with the oral form of the same drug.

Example drugs

Haloperidol Paliperidone Aripiprazole medroxyprogesterone leuprorelin benzathine benzylpenicillin
TRIn Turkish

Depo Enjeksiyon

Genellikle intramüsküler veya subkutan uygulanan, enjeksiyon yerinde bir depo oluşturarak ilacın haftalar ile aylar boyunca yavaş salınmasını sağlayan parenteral preparattır.

Uzatılmış salım; lipofilik esterlerin yağlı çözeltileri (haloperidol dekanoat, flufenazin dekanoat), sulu mikro- veya nanokristal süspansiyonlar (paliperidon palmitat, aripiprazol, medroksiprogesteron asetat), biyolojik olarak parçalanabilen polimer mikroküreler veya implantlar (löprorelin [löprolid], goserelin) ve az çözünen tuzlar (benzatin benzilpenisilin) ile sağlanır. Depodan absorpsiyon hız sınırlayıcı olduğundan görünür yarılanma ömrü eliminasyonu değil salımı yansıtır (flip-flop kinetiği).

Bazı ürünlerde kararlı duruma ancak birkaç ay sonra ulaşıldığından, tedavi başlangıcında oral ilaçla destek veya bir yükleme rejimi gerekebilir.

Uzun etkili enjektabl antipsikotikler tedaviye uyumu artırır; ancak advers etkiler son enjeksiyondan sonra haftalarca sürebileceğinden, depo tedaviye geçmeden önce aynı ilacın oral formuyla tolerabilite doğrulanmalıdır.

Diğer adları:Uzun etkili enjektabl · Depo preparat
Updated 24.09.2026 0 views Educational reference — verify against current sources before clinical use.

Read next

Parenteral AdministrationParenteral Uygulama

Administration of a drug by a route that bypasses the gastrointestinal tract, usually by injection or infusion (intravenous, intramuscular, subcutaneous, intradermal, intrathecal and others).

 Modified-Release FormulationDeğiştirilmiş Salımlı Formülasyon

A dosage form in which the rate, timing or site of drug release is deliberately altered from that of a conventional product, as in prolonged-release, delayed-release and pulsatile preparations.

 Flip-Flop KineticsFlip-Flop Kinetiği

A situation in which the absorption rate constant is smaller than the elimination rate constant (ka < ke), so that the terminal slope of the plasma concentration–time curve reflects absorption rather than elimination.

 Steady-State ConcentrationKararlı Durum Konsantrasyonu

The constant plasma drug concentration achieved when the rate of drug administration equals the rate of elimination during repeated dosing.

 Loading DoseYükleme Dozu

An initial dose, or series of doses, larger than the maintenance dose, given to reach the target plasma concentration rapidly instead of waiting 4–5 half-lives for accumulation.

 Medication AdherenceTedaviye Uyum

The extent to which a patient's medication-taking behaviour corresponds with the recommendations agreed with the prescriber.