General Pharmacology

Clinical Pharmacology

TRKlinik Farmakoloji

It is the branch of science that comprehensively examines the relationship of drugs that have reached the clinical trial phase on volunteer patients and healthy individuals in all aspects.

In depth

Clinical pharmacology integrates pharmacokinetics, pharmacodynamics, pharmacogenomics and clinical trial methodology. Its activities span first-in-human and dose-finding studies, characterisation of drug behaviour in special populations such as renal or hepatic impairment, interaction studies and model-informed drug development, through to evidence-based prescribing, therapeutic drug monitoring, pharmacovigilance and formulary decisions.

It bridges basic pharmacology and clinical medicine: clinical pharmacology data underpin the posology, special-population and interaction sections of the SmPC (KÜB). The rational use of medicines (akılcı ilaç kullanımı), promoted by WHO and in Turkey by TİTCK, draws directly on its principles.

Clinical pearl

Complex cases involving multiple interacting drugs, organ impairment, unexpected drug levels or suspected ADRs benefit from a structured clinical pharmacology review of dose, exposure and response.

TRIn Turkish

Klinik Farmakoloji

Klinik deneme dönemine ulaşmış ilaçların gönüllü hastalar ve sağlıklı bireyler üzerindeki ilişkiyi tüm yönüyle inceleyen bilim dalıdır.

Klinik farmakoloji farmakokinetik, farmakodinamik, farmakogenomik ve klinik araştırma metodolojisini bir araya getirir. Çalışma alanı insanda ilk kez uygulama ve doz bulma çalışmalarından böbrek veya karaciğer yetmezliği gibi özel popülasyonlarda ilaç davranışının belirlenmesine, etkileşim çalışmalarına ve model destekli ilaç geliştirmeye; oradan da kanıta dayalı reçetelemeye, terapötik ilaç izlemine, farmakovijilansa ve formüler kararlarına uzanır.

Temel farmakoloji ile klinik tıp arasında köprü kurar: KÜB'ün pozoloji, özel popülasyonlar ve etkileşimler bölümleri klinik farmakoloji verilerine dayanır. DSÖ'nün ve Türkiye'de TİTCK'nın desteklediği akılcı ilaç kullanımı doğrudan bu disiplinin ilkelerinden beslenir.

Çok sayıda etkileşimli ilaç, organ yetmezliği, beklenmeyen ilaç düzeyleri veya şüpheli advers reaksiyonlar içeren karmaşık olgular; doz, maruziyet ve yanıtın yapılandırılmış bir klinik farmakoloji değerlendirmesinden yarar görür.

Updated 24.09.2026 14 views Educational reference — verify against current sources before clinical use.

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PharmacologyFarmakoloji

Pharmacology means the science of the drugs

 PharmacokineticsFarmakokinetik

The branch of pharmacology that describes what the body does to a drug: the time course of its absorption, distribution, metabolism and excretion (ADME) and the resulting concentrations in plasma and tissues.

 PharmacodynamicsFarmakodinamik

The branch of pharmacology that studies what a drug does to the body: the biochemical and physiological effects of drugs, their mechanisms of action and the relationship between drug concentration and response.

 Therapeutic Drug MonitoringTerapötik İlaç İzlemi

The measurement of drug concentrations in blood at defined times, interpreted in the clinical context, to individualise dosing so as to maximise efficacy and minimise toxicity.

 PharmacotherapyFarmakoterapi

The treatment or prevention of disease by means of drugs, as distinct from surgical, physical, psychological or other non-drug interventions.

 Phase I Clinical TrialFaz I Klinik Araştırma

The first stage of testing an investigational drug in humans, usually in a small number of healthy volunteers, designed mainly to assess safety, tolerability, pharmacokinetics and, where possible, pharmacodynamics.