Adverse Reactions & Pharmacovigilance

Rebound Effect

TRRebound Etkisi
Also known as:Rebound phenomenon

The return of the condition being treated, at an intensity exceeding pre-treatment levels, after a drug is stopped or its dose is rapidly reduced.

In depth

Rebound arises from adaptive changes during treatment that outlast the drug. Chronic beta-blockade up-regulates beta-adrenoceptors, so abrupt withdrawal can cause tachycardia, hypertension and myocardial ischaemia; clonidine withdrawal produces rebound sympathetic overactivity and hypertension; stopping a proton pump inhibitor causes rebound acid hypersecretion driven by hypergastrinaemia; and prolonged use of topical nasal decongestants leads to rebound congestion (rhinitis medicamentosa). Rebound insomnia can follow short-acting hypnotics.

Rebound differs from relapse, in which symptoms simply return to their original level, and from withdrawal syndrome, in which new symptoms unrelated to the original condition appear. Tapering the dose allows the adaptive changes to reverse gradually.

Clinical pearl

Beta-blockers and clonidine should not be stopped abruptly, especially in coronary disease; after stopping a PPI, transient dyspepsia from rebound acid secretion can be mistaken for a continued need for therapy.

Example drugs

Propranolol Metoprolol Clonidine Omeprazole Oxymetazoline
TRIn Turkish

Rebound Etkisi

Bir ilaç kesildiğinde veya dozu hızla azaltıldığında, tedavi edilen durumun tedavi öncesindekinden daha şiddetli biçimde geri dönmesidir.

Rebound, tedavi sırasında gelişen ve ilacın etkisinden daha uzun süren adaptif değişikliklerden kaynaklanır. Kronik beta blokaj beta adrenoseptörlerinde up-regülasyona yol açtığından ani kesilme taşikardi, hipertansiyon ve miyokard iskemisine neden olabilir; klonidinin kesilmesi rebound sempatik aşırı aktivite ve hipertansiyon, proton pompası inhibitörünün kesilmesi hipergastrinemiye bağlı rebound asit hipersekresyonu oluşturur; topikal nazal dekonjestanların uzun süreli kullanımı ise rebound konjesyona (rinitis medikamentoza) yol açar. Kısa etkili hipnotiklerden sonra rebound insomni görülebilir.

Rebound, belirtilerin yalnızca başlangıçtaki düzeyine döndüğü nüksten (relaps) ve özgün hastalıkla ilgisi olmayan yeni belirtilerin ortaya çıktığı yoksunluk sendromundan farklıdır. Dozun azaltılarak kesilmesi adaptif değişikliklerin kademeli olarak geri dönmesine olanak tanır.

Beta blokörler ve klonidin, özellikle koroner hastalığı olanlarda, aniden kesilmemelidir; PPİ kesildikten sonra rebound asit salgısına bağlı geçici dispepsi tedaviye devam gereksinimi olarak yanlış yorumlanabilir.

Diğer adları:Rebound fenomeni · Geri tepme etkisi
Updated 24.09.2026 0 views Educational reference — verify against current sources before clinical use.

Read next

Withdrawal SyndromeYoksunluk Sendromu

A characteristic cluster of signs and symptoms that follows abrupt discontinuation, rapid dose reduction or antagonist reversal of a drug to which the body has adapted during prolonged use.

 TaperingAzaltarak Kesme

The gradual, planned reduction of a drug's dose over time before stopping it, to avoid withdrawal symptoms, rebound, disease flare or insufficient endogenous hormone production.

 Receptor Up-RegulationReseptör Up-Regülasyonu

An increase in the number or sensitivity of receptors, typically after prolonged receptor blockade or reduced exposure to the endogenous agonist (e.g. denervation), leading to tissue supersensitivity.

 Deprescribingİlaç Azaltma (Deprescribing)

The planned and supervised process of reducing the dose of, or stopping, medicines that may be causing harm or are no longer providing sufficient benefit.

 ToleranceTolerans

A gradual reduction in response to a drug with repeated or continuous exposure, so that a higher dose is needed to reproduce the original effect; it develops over days to weeks.

 TachyphylaxisTaşifilaksi

A rapidly developing decrease in response to a drug after repeated doses over a short period (minutes to hours), which often cannot be overcome by increasing the dose.