Definition
The metabolism of a drug in the liver (or gut wall) before it reaches systemic circulation, often reducing the bioavailability of orally administered drugs.
English
First-Pass Effect
The metabolism of a drug in the liver (or gut wall) before it reaches systemic circulation, often reducing the bioavailability of orally administered drugs.
Türkçe
İlk Geçiş Etkisi
Oral yolla verilen ilacın sistemik dolaşıma ulaşmadan önce karaciğerde (veya bağırsak duvarında) metabolize olması; genellikle biyoyararlanımı azaltır.
Synonyms
First-pass metabolism
presystemic metabolism
presystemic elimination
Share