About this pathway
The major metabolite of avatrombopag is a 4‐hydroxy derivative 4-(decarboxy)-4-hydroxy-avatrombopag detected in feces and approximately 44% of administered dose [Article:29341245]. CYP2C9 and CYP3A4 contribute equally to form the 4‐hydroxy metabolite [Article:29341245]. While CYP2C9 polymorphisms have been shown to impact avatrombopag PK, they did not significantly affect platelet levels in healthy volunteers, although more studies are needed in patients {PMID:28339166, 29341245, 40573298]. ABCB1 is involved in the transport of avatrombopag [Article:40573298].
Reactions & interactions (5)
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Biochemical Reaction
avatrombopag → 4-(decarboxy)-4-hydroxy-avatrombopag
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Catalysis
ABCB1 → Transport
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Catalysis
CYP2C9 → Biochemical Reaction
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Catalysis
CYP3A4 → Biochemical Reaction
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Transport
avatrombopag → avatrombopag
Edit history (1)
- 2025-07-02 Create