In Progress: Furmonertinib Pathway, Pharmacokinetics — pathway diagram from PharmGKB / ClinPGx
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About this pathway
Furmonertinib is metabolized by CYP3A4 and CYP2C9 to form active metabolite desmethylfurmonertinib (also known as AST5902) [Article:40525261]. Both are also further metabolized by CYP3A4 and to a lesser extent by CYP2C9 and CYP1A2 to form unknown metabolites [Article:40525261].
Reactions & interactions (5)
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Activation
furmonertinib
→
CYP3A4
-
Activation
desmethylfurmonertinib
→
CYP3A4
-
Biochemical Reaction
furmonertinib
→
desmethylfurmonertinib
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Catalysis
CYP3A4
→
Biochemical Reaction
-
Catalysis
CYP2C8
→
Biochemical Reaction
