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PharmGKB · ClinPGx

In Progress: Loperamide Pathway, Pharmacokinetics/Pharmacodynamics

PA166429041 Last updated January 2026 Caroline F. Thorn
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Drugs & chemicals
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Genes
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Conditions
8
Reactions
In Progress: Loperamide Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram
In Progress: Loperamide Pathway, Pharmacokinetics/Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
Click to enlarge

Reactions & interactions (8)

  • Activation
    loperamide → OPRM1
  • Biochemical Reaction
    loperamide → n-desmethyl loperamide
  • Catalysis
    CYP2C8 → Biochemical Reaction
  • Catalysis
    CYP2D6 → Biochemical Reaction
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Catalysis
    ABCB1 → Transport
  • Inhibition
    OPRM1 → Diarrhea
  • Transport
    loperamide → loperamide

Edit history (1)

  • 2026-01-28 Create
In Progress: Loperamide Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram (enlarged)