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PharmGKB · ClinPGx

In Progress: Phenobarbital and Methylphenobarbital Pathway, Pharmacokinetics/Pharmacodynamics

PA166348361 Last updated January 2026 Caroline F. Thorn
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Genes
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Conditions
23
Reactions
In Progress: Phenobarbital and Methylphenobarbital Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram
In Progress: Phenobarbital and Methylphenobarbital Pathway, Pharmacokinetics/Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
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Reactions & interactions (23)

  • Activation
    NR1I2 CYP2B6
  • Activation
    NR1I2 UGT1A1
  • Activation
    NR1I3 CYP3A4
  • Activation
    phenobarbital NR1I2
  • Activation
    phenobarbital NR1I3
  • Activation
    NR1I3 UGT1A1
  • Activation
    NR1I2 CYP3A4
  • Biochemical Reaction
    r-methylphenobarbital 4-hydroxyphenobarbital
  • Biochemical Reaction
    phenobarbital phenobarbital n-glucoside
  • Biochemical Reaction
    4-hydroxyphenobarbital p-hydroxy phenobarbital glucuronide
  • Biochemical Reaction
    primidone phenobarbital
  • Biochemical Reaction
    primidone phenylethylmalondiamide
  • Biochemical Reaction
    s-methylphenobarbital phenobarbital
  • Biochemical Reaction
    phenobarbital 4-hydroxyphenobarbital
  • Biochemical Reaction
    r-methylphenobarbital phenobarbital
  • Catalysis
    CYP2C19 Biochemical Reaction
  • Catalysis
    CYP2B6 Biochemical Reaction
  • Catalysis
    CYP2C19 Biochemical Reaction
  • Catalysis
    CYP2E1 Biochemical Reaction
  • Catalysis
    CYP2C9 Biochemical Reaction
  • Catalysis
    CYP2B6 Biochemical Reaction
  • Leads To
    methylphenobarbital r-methylphenobarbital
  • Leads To
    methylphenobarbital s-methylphenobarbital

Edit history (3)

  • 2024-08-20 Create
  • 2024-08-30 Update Removed CYP3A and replaced with CYP3A4.
  • 2026-01-27 Update Added methylphenobarbital enantiomer specific metabolism.
In Progress: Phenobarbital and Methylphenobarbital Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram (enlarged)