Reactions & interactions (23)
-
Activation
NR1I2 → CYP2B6
-
Activation
NR1I2 → UGT1A1
-
Activation
NR1I3 → CYP3A4
-
Activation
phenobarbital → NR1I2
-
Activation
phenobarbital → NR1I3
-
Activation
NR1I3 → UGT1A1
-
Activation
NR1I2 → CYP3A4
-
Biochemical Reaction
r-methylphenobarbital → 4-hydroxyphenobarbital
-
Biochemical Reaction
phenobarbital → phenobarbital n-glucoside
-
Biochemical Reaction
4-hydroxyphenobarbital → p-hydroxy phenobarbital glucuronide
-
Biochemical Reaction
primidone → phenobarbital
-
Biochemical Reaction
primidone → phenylethylmalondiamide
-
Biochemical Reaction
s-methylphenobarbital → phenobarbital
-
Biochemical Reaction
phenobarbital → 4-hydroxyphenobarbital
-
Biochemical Reaction
r-methylphenobarbital → phenobarbital
-
Catalysis
CYP2C19 → Biochemical Reaction
-
Catalysis
CYP2B6 → Biochemical Reaction
-
Catalysis
CYP2C19 → Biochemical Reaction
-
Catalysis
CYP2E1 → Biochemical Reaction
-
Catalysis
CYP2C9 → Biochemical Reaction
-
Catalysis
CYP2B6 → Biochemical Reaction
-
Leads To
methylphenobarbital → r-methylphenobarbital
-
Leads To
methylphenobarbital → s-methylphenobarbital
Edit history (3)
- 2024-08-20 Create
- 2024-08-30 Update Removed CYP3A and replaced with CYP3A4.
- 2026-01-27 Update Added methylphenobarbital enantiomer specific metabolism.