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PharmGKB · ClinPGx

Antimigraine Preparations Pathway, Pharmacodynamics

PA166321041 Last updated November 2023 Caroline F. Thorn
19/19
Drugs & chemicals
0
Genes
3/3
Conditions
34
Reactions
Antimigraine Preparations Pathway, Pharmacodynamics pathway diagram
Antimigraine Preparations Pathway, Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
Click to enlarge

Reactions & interactions (34)

  • Activation
    CALCA → CALCRL
  • Activation
    triptans → HTR1B
  • Activation
    dihydroergotamine → HTR1F
  • Activation
    lasmiditan → HTR1F
  • Activation
    dihydroergotamine → HTR1D
  • Activation
    dihydroergotamine → HTR1B
  • Activation
    RAMP1 → CALCRL
  • Activation
    triptans → HTR1D
  • Inhibition
    olcegepant → RAMP1
  • Inhibition
    atogepant → CALCA
  • Inhibition
    erenumab → CALCRL
  • Inhibition
    ubrogepant → CALCA
  • Inhibition
    rimegepant → CALCA
  • Inhibition
    galcanezumab → CALCA
  • Inhibition
    telcagepant → RAMP1
  • Inhibition
    HTR1D → CALCA
  • Inhibition
    botulinum toxin type a → SNAP25
  • Inhibition
    fremanezumab → CALCA
  • Inhibition
    HTR1B → CALCA
  • Inhibition
    eptinezumab → CALCA
  • Leads To
    SNAP25 → TRPV1
  • Leads To
    TRPA1 → Pain
  • Leads To
    VIPR2 → Migraine without Aura
  • Leads To
    VIP → VIPR2
  • Leads To
    TRPV1 → Migraine without Aura
  • Leads To
    CALCRL → Migraine without Aura
  • Leads To
    CALCRL → Migraine with Aura
  • Leads To
    SNAP25 → TRPA1
  • Leads To
    ADCYAP1 → ADCYAP1R1
  • Leads To
    TRPV1 → Migraine with Aura
  • Leads To
    VIPR1 → Migraine without Aura
  • Leads To
    SNAP25 → CALCRL
  • Leads To
    ADCYAP1R1 → Migraine without Aura
  • Leads To
    VIP → VIPR1

Edit history (1)

  • 2023-11-13 Create
Antimigraine Preparations Pathway, Pharmacodynamics pathway diagram (enlarged)