All PharmGKB pathways
PharmGKB · ClinPGx

In Progress: Aprepitant Pathway, Pharmacokinetics/Pharmacodynamics

PA166337541 Last updated May 2024 Caroline F. Thorn
2/6
Drugs & chemicals
0
Genes
1/1
Conditions
16
Reactions
In Progress: Aprepitant Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram
In Progress: Aprepitant Pathway, Pharmacokinetics/Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
Click to enlarge

Reactions & interactions (16)

  • Biochemical Reaction
    aprepitant → aprepitant metabolite m4
  • Biochemical Reaction
    aprepitant → aprepitant metabolite m1
  • Biochemical Reaction
    aprepitant → aprepitant metabolite m3
  • Biochemical Reaction
    fosaprepitant → aprepitant
  • Biochemical Reaction
    aprepitant metabolite m1 → aprepitant metabolite m2
  • Catalysis
    CYP1A2 → Biochemical Reaction
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Catalysis
    CYP2C19 → Biochemical Reaction
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Catalysis
    CYP2C19 → Biochemical Reaction
  • Catalysis
    CYP1A2 → Biochemical Reaction
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Inhibition
    aprepitant → TACR1
  • Inhibition
    aprepitant → CYP3A4
  • Leads To
    TACR1 → Nausea

Edit history (1)

  • 2024-05-08 Create
In Progress: Aprepitant Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram (enlarged)