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PharmGKB · ClinPGx

In Progress: Vandetanib Pathway, Pharmacokinetics/Pharmacodynamics

PA166322741 Last updated December 2023 Caroline F. Thorn
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Conditions
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In Progress: Vandetanib Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram
In Progress: Vandetanib Pathway, Pharmacokinetics/Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
Click to enlarge

About this pathway

Work in progress...

Reactions & interactions (14)

  • Biochemical Reaction
    vandetanib → vandetanib n-oxide
  • Biochemical Reaction
    vandetanib → n-desmethyl vandetanib
  • Catalysis
    FMO1 → Biochemical Reaction
  • Catalysis
    FMO3 → Biochemical Reaction
  • Catalysis
    CYP3A5 → Biochemical Reaction
  • Catalysis
    CYP2C8 → Biochemical Reaction
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Catalysis
    CYP1A1 → Biochemical Reaction
  • Catalysis
    CYP2D6 → Biochemical Reaction
  • Inhibition
    vandetanib → EGFR
  • Inhibition
    vandetanib → KDR
  • Inhibition
    vandetanib → RET
  • Leads To
    KCNH2 → Acquired Long QT Syndrome (aLQTS)
  • Leads To
    vandetanib → KCNH2

Edit history (1)

  • 2023-12-06 Create
In Progress: Vandetanib Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram (enlarged)