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PharmGKB · ClinPGx

In Progress: Alectinib Pathway, Pharmacokinetics/Pharmacodynamics

PA166306841 Last updated August 2024 Caroline F. Thorn
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In Progress: Alectinib Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram
In Progress: Alectinib Pathway, Pharmacokinetics/Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
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About this pathway

Work in progress.

Reactions & interactions (9)

  • Biochemical Reaction
    alectinib → alectinib metabolite M6
  • Biochemical Reaction
    alectinib → alectinib metabolite M1b
  • Biochemical Reaction
    alectinib → alectinib metabolite M4
  • Biochemical Reaction
    alectinib → alectinib metabolite M1a
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Inhibition
    alectinib metabolite M4 → ALK
  • Inhibition
    alectinib → ALK
  • Inhibition
    alectinib → ABCB1
  • Inhibition
    alectinib → ABCG2

Edit history (2)

  • 2023-07-12 Create
  • 2024-08-30 Update Removed CYP3A from gpml and replaced with CYP3A4.
In Progress: Alectinib Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram (enlarged)