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PharmGKB · ClinPGx

In Progress: Lipid modifying agents Pathway, Pharmacodynamics

PA166306881 Last updated July 2023 Caroline F. Thorn
5/6
Drugs & chemicals
1
Genes
1/1
Conditions
15
Reactions
In Progress: Lipid modifying agents Pathway, Pharmacodynamics pathway diagram
In Progress: Lipid modifying agents Pathway, Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
Click to enlarge

About this pathway

Work in progress...

Reactions & interactions (15)

  • Inhibition
    inclisiran → PCSK9
  • Inhibition
    evinacumab → ANGPTL3
  • Inhibition
    lomitapide → MTTP
  • Inhibition
    evolocumab → PCSK9
  • Inhibition
    alirocumab → PCSK9
  • Leads To
    LDLR → MTTP
  • Leads To
    PCSK9 → LDLR
  • Leads To
    LDLR → low density lipoprotein
  • Leads To
    PCSK9 → familial hypercholesterolemia
  • Leads To
    LDLR → familial hypercholesterolemia
  • Leads To
    APOB → LDLR
  • Leads To
    low density lipoprotein → LDLR
  • Leads To
    MTTP → APOB
  • Leads To
    ANGPTL3 → low density lipoprotein
  • Leads To
    APOB → familial hypercholesterolemia

Edit history (2)

  • 2023-07-12 Create
  • 2023-07-13 Update Added related pathways
In Progress: Lipid modifying agents Pathway, Pharmacodynamics pathway diagram (enlarged)