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PharmGKB · ClinPGx

In Progress: Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

PA166278901 Last updated September 2022 Caroline F. Thorn
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In Progress: Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram
In Progress: Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
Click to enlarge

About this pathway

Work in progress.

Reactions & interactions (14)

  • Activation
    dabrafenib → CYP2C8
  • Activation
    dabrafenib → CYP3A4
  • Biochemical Reaction
    hydroxy dabrafenib → carboxy dabrafenib
  • Biochemical Reaction
    carboxy dabrafenib → desmethyl dabrafenib
  • Biochemical Reaction
    dabrafenib → hydroxy dabrafenib
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Catalysis
    CYP2C8 → Biochemical Reaction
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Inhibition
    dabrafenib → ABCB1
  • Inhibition
    dabrafenib → ABCG2
  • Inhibition
    dabrafenib → BRAF
  • Inhibition
    dabrafenib → CYP3A4
  • Inhibition
    dabrafenib → CYP2C8
  • Transport
    carboxy dabrafenib → carboxy dabrafenib

Edit history (1)

  • 2022-09-27 Create
In Progress: Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram (enlarged)