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PharmGKB · ClinPGx

In Progress: Mitotane Pathway, Pharmacokinetics/Pharmacodynamics

PA166279441 Last updated September 2022 Caroline F. Thorn
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Conditions
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Reactions
In Progress: Mitotane Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram
In Progress: Mitotane Pathway, Pharmacokinetics/Pharmacodynamics — pathway diagram from PharmGKB / ClinPGx
Click to enlarge

About this pathway

Work in progress.

Reactions & interactions (22)

  • Activation
    NR1I2 → ABCG2
  • Activation
    o,p'-DDE → NR1I2
  • Activation
    o,p'-DDE → CYP1A2
  • Activation
    NR1I2 → UGT1A3
  • Activation
    o,p'-DDE → CYP1A1
  • Activation
    NR1I2 → CYP3A4
  • Activation
    mitotane → NR1I2
  • Activation
    mitotane → CYP1A2
  • Activation
    NR1I2 → ABCB1
  • Activation
    mitotane → CYP1A1
  • Biochemical Reaction
    mitotane → o,p'-DDE
  • Biochemical Reaction
    mitotane → o,p'-DDA
  • Catalysis
    CYP2W1 → Biochemical Reaction
  • Inhibition
    o,p'-DDA → SLCO1B1
  • Inhibition
    mitotane → CYP3A4
  • Inhibition
    mitotane → SOAT1
  • Inhibition
    o,p'-DDE → CYP3A4
  • Inhibition
    o,p'-DDE → CYP2D6
  • Inhibition
    mitotane → CYP2C19
  • Inhibition
    o,p'-DDE → CYP2C19
  • Inhibition
    o,p'-DDA → CYP2C19
  • Inhibition
    mitotane → CYP2D6

Edit history (1)

  • 2022-09-29 Create
In Progress: Mitotane Pathway, Pharmacokinetics/Pharmacodynamics pathway diagram (enlarged)