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PharmGKB · ClinPGx

In Progress: Dolutegravir Pathway, Pharmacokinetics

PA166270421 Last updated May 2022 Caroline F. Thorn
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Conditions
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Reactions
In Progress: Dolutegravir Pathway, Pharmacokinetics pathway diagram
In Progress: Dolutegravir Pathway, Pharmacokinetics — pathway diagram from PharmGKB / ClinPGx
Click to enlarge

About this pathway

Work in progress

Reactions & interactions (10)

  • Biochemical Reaction
    dolutegravir → dolutegravir M1
  • Biochemical Reaction
    dolutegravir → dolutegravir glucuronide
  • Catalysis
    ABCB1 → Transport
  • Catalysis
    ABCG2 → Transport
  • Catalysis
    CYP3A4 → Biochemical Reaction
  • Catalysis
    UGT1A1 → Biochemical Reaction
  • Catalysis
    UGT1A3 → Biochemical Reaction
  • Catalysis
    UGT1A9 → Biochemical Reaction
  • Inhibition
    dolutegravir → SLC22A2
  • Transport
    dolutegravir → dolutegravir

Edit history (1)

  • 2022-05-10 Create
In Progress: Dolutegravir Pathway, Pharmacokinetics pathway diagram (enlarged)